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High Fat Diet Destroys Arteries Early

Published on 11 April, 2012
High Fat Diet Destroys Arteries Early

A high fat diet can destroy yourarteries earlier than what was previously expected. It has also been identifiedas one of the primary causative factors of high blood pressure (BP).

 MarieBillaud and colleagues, from the University of Virginia School of Medicine,initiated a study in mice and the results have been reported in the Journal of Cardiovascular TranslationalResearch.

 As anindividual grows older, the internal wall of the large intestine becomes thinnerand increasingly elastic and this in turn leads to obesity, metabolic disease,atherosclerosis and abnormally high BP.

 Although,at present, researchers and physicians are engaged in measuring arterialcompliance of the large arteries (as a means to evaluate arterial stiffness)during the advanced stages of a health condition, it is not expected to provideadequate information about the initiation or progress of the disease.

 Earlierstudies have indicated that changes in the walls of small arteries are the mostpotent indicators of CVD and, early detection of these changes is important inthe treatment and management of the condition.

 Billaudand colleagues, as part of their research, compared the arterial compliance oftwo arteries of different sizes-the carotid artery (large) and thoracodorsalartery (smaller)- in mice.

 The micewere divided into two groups. One of the groups was given high -fat diet forsix weeks and the other, which formed the control group, was fed a normal diet.

 Subsequentlyscientists observed rapid changes in the structural and mechanical propertiesof the small arteries in mice that were fed for six months on high-fat diet.

 Thescientists conclusively state, "These results suggest that, at an earlystage of obesity, the structural properties of small and large arteries arealtered whereas arterial stiffness is only observed in small vessels."

 Otherstudies have shown that in humans the adipose cells surrounding the coronaryarteries tend to become highly inflamed and this, in turn, could causeinflammation in the blood cells surrounding the arteries. When mice were fedwith high-fat diet the inflammation of the fat tissues around the arteries increased.

 The fact remains that inflammation of the adipose tissues around arteries is an importantevent in atherosclerosis, and that the lipid or cholesterol levels in thesepatients can appear normal.

 Research therefore cautions us to go easy on high -fat diet and prompts us to adopt regular exercise to stay fit. After all, a healthy heart not only prolongs life but also adds quality to one's years.!

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